Metformin has been shown to extend lifespan in various organisms, including mammals ( R, R).
Our view: We are cautiously optimistic about metformin, keeping in mind some caveats. Metformin (prescription drug): 800 mg, in the evening We suggest you opt for the superior pterostilbene.ģ. Sinclair has a long history with the molecule, being its biggest proponent for many years.
DAY R SURVIVAL COOKING RECIPES PLUS
In it, David Sinclair says that pterostilbene is essentially resveratrol plus three methyl groups, which adds the substantial benefit of it also being an NAD+ booster. Listen to David Sinclair speak about pterostilbene and resveratrol in this short clip. Various studies show that pterostilbene works better than resveratrol regarding anticancer, antidiabetic, and cardioprotective effects ( R, R, R). This increases the bioavailability, and enhances the pharmacokinetic profile and pharmacological activities of pterostilbene” ( R).įurther, pterostilbene contains three methyl groups that resveratrol doesn’t, which the body can use for, among other things, methylation, which is required for proper gene function. For example, a paper that compares resveratrol to pterostilbene states, “Although there are structural and bioactivity similarities between resveratrol and pterostilbene, pharmacological properties of pterostilbene are often stronger than those of resveratrol,” and “Overall, pterostilbene performs better in membrane permeability and metabolic stability than resveratrol. Pterostilbene is a molecule that looks very similar to resveratrol, but it is absorbed considerably better and is far more stable in the human body. Therefore, pterostilbene is a better alternative. However, resveratrol is difficult to be absorbed by the gut, and the little resveratrol that ends up in the body is broken down very quickly. Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is needed to fuel the sirtuins. Studies have shown that resveratrol can reduce the risk of heart disease, cancer, and neurodegeneration.ĭavid Sinclair believes that resveratrol works synergistically with NMN.
DAY R SURVIVAL COOKING RECIPES SKIN
Resveratrol is a stilbenoid found in the skin of grapes in low amounts. Our view: We are lukewarm about resveratrol.
Vitamin K2: ideally 180 to 360 micrograms per day.
Vitamin D3: ideally 4,000 to 5,000 IU per day.Resveratrol: 1g per day, in the morning.Nicotinamide mononucleotide (NMN): 1g per day, in the morning.Sinclair’s supplement and longevity drug stack likely looks as follows: We don’t know if he still takes these supplements or whether he takes additional supplements that are not included on this list.įor example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.īased on multiple, recent interviews and his book, Dr. We compiled this list from interviews and books in which Dr. Sinclair has made a point to not promote or endorse any supplement products. You may have come across his published, New York Times best-selling book on aging, Lifespan: Why We Age – And Why We Don’t Have To, going deeper into those subjects (you can find our favorite longevity books here). David Sinclair’s main research interest is the epigenetics of aging, with a focus on epigenetic reprogramming of aging (e.g., reversing aging via Yamanaka factors), NAD+ metabolism and sirtuins, and NAD+ precursors like NR and NMN. David Sinclair is a professor at Harvard University who has been studying aging for the better part of his academic career.ĭr.
0 kommentar(er)
